What does this research mean for the field?

Exercise training promotes the development of epicardial coronary collateral connections following gradual coronary occlusion, but does not improve perfusion or protect against subendocardial ischemia in the collateral-supplied myocardium. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 1979CirculationOpen Access

Exercise can promote coronary collateral development without improving perfusion of ischemic myocardium.

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Why the study?

Does exercise training improve coronary collateral function and myocardial perfusion in dogs with gradual coronary occlusion?

Structured PICO

Does exercise training improve coronary collateral function and myocardial perfusion in dogs with gradual coronary occlusion?

Population

33 dogs with gradual proximal left circumflex coronary artery occlusion

Intervention

Exercise training

Comparator

Sedentary group

Outcome

Coronary collateral function evaluated at 5 or 8 weekssurrogate

In a canine model of coronary occlusion, exercise training promotes epicardial collateral development but fails to improve subendocardial perfusion during tachycardia-provoked ischemia.

Discussion

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Implication

Exercise may enhance epicardial collaterals in canine models; leaves open translation to subendocardial protection or human disease.

Cite This Study

Neill et al. (1979) studied this question.

synapsesocial.com/papers/6a1be0616f692abb725ef0b8 https://doi.org/10.1161/01.cir.60.7.1513

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Exercise can promote coronary collateral development without improving perfusion of ischemic myocardium.

Structured PICO

Discussion

Implication

Cite This Study

Exercise can promote coronary collateral development without improving perfusion of ischemic myocardium.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider