What does this research mean for the field?

One month after gradual coronary occlusion without myocardial infarction, resting myocardial blood flow in the collateral-dependent area remains normal, but exercise induces a markedly heterogeneous response ranging from normal perfusion to severe subendocardial underperfusion. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 1983AJP Heart and Circulatory Physiology

Myocardial blood flow during exercise after gradual coronary occlusion in the dog

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Why the study?

Does treadmill exercise affect myocardial blood flow in dogs with gradual total coronary occlusion compared to normal controls?

Structured PICO

Does treadmill exercise affect myocardial blood flow in dogs with gradual total coronary occlusion compared to normal controls?

Population

14 dogs with gradual total coronary occlusion (via Ameroid constrictor on left circumflex or left anterior descending coronary artery) without myocardial infarction, and 7 normal control dogs (total n=21).

Intervention

Treadmill exercise at two levels (light: ~180 beats/min; heavy: ~230 beats/min) 1 month after Ameroid implantation.

Comparator

Resting conditions and normal control dogs.

Outcome

Myocardial blood flow volume and transmural distribution measured with radioactive microspheres.surrogate

This study demonstrates that normal resting myocardial blood flow in collateral-dependent areas does not guarantee adequate perfusion during exercise stress.

Discussion

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Implication

Normal resting flow may mask exercise-induced subendocardial ischemia in collateral-dependent myocardium; leaves open relevance to human chronic coronary disease.

Cite This Study

Bache et al. (1983) studied this question.

synapsesocial.com/papers/6a11fb2607103abb49ad109e https://doi.org/10.1152/ajpheart.1983.245.1.h131

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Implication

Normal resting flow may mask exercise-induced subendocardial ischemia in collateral-dependent myocardium; leaves open relevance to human chronic coronary disease.

Myocardial blood flow during exercise after gradual coronary occlusion in the dog

Structured PICO

Discussion

Implication

Cite This Study

Myocardial blood flow during exercise after gradual coronary occlusion in the dog

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider