Key result
Exercise with coronary artery stenosis in dogs caused transmural redistribution of myocardial blood flow, leading to subendocardial underperfusion proportional to the degree of inflow restriction.
Population
9 dogs with electromagnetic flowmeter probes and hydraulic occluders on the left circumflex coronary artery
Comparison
Treadmill exercise during partial inflation of… vs Treadmill exercise during unrestricted coronary…
Design
Preclinical
Authors
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Suggests mechanism of exertional subendocardial ischemia in stenosis; leaves open translation to human CAD testing and management.
In a canine model, exercise with restricted coronary inflow causes transmural redistribution of myocardial blood flow, leading to subendocardial underperfusion proportional to the stenosis severity.
Ball et al. (1976) studied Coronary artery stenosis (n=9). Partial inflation of hydraulic occluder (coronary artery stenosis) vs. Unrestricted coronary artery inflow (control exercise) was evaluated on Transmural myocardial blood flow during exercise. Exercise with coronary artery stenosis in dogs caused transmural redistribution of myocardial blood flow, leading to subendocardial underperfusion proportional to the degree of inflow restriction.
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