Key result
Chronic circumflex occlusion reduces exercise-induced myocardial blood flow ~47% compared to sham operation.
Why the study?
Previous investigations had not compared myocardial blood flow and cardiac functional responses during exercise in dogs with chronic coronary artery constriction versus sham-operated controls.
Absolute Event Rate: 1.45% vs 2.74%
In a canine model of chronic coronary occlusion, collateralized myocardium exhibits limited active hyperemia and reduced cardiac performance during severe exertion compared to normal hearts.
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Collateral formation enables equivalent exercise hyperemia in native and collateral-dependent myocardium in dogs; leaves open relevance to clinical coronary disease.
Longhurst et al. (1985) studied Chronic constriction of a coronary artery. Ameroid occluder placement around proximal left circumflex artery vs. Sham operation was evaluated on Average transmural myocardial blood flow during severe exercise (ml/min/g). Chronic circumflex occlusion in dogs resulted in smaller increases in average transmural myocardial blood flow during severe exercise compared to sham operation (1.45 vs 2.74 ml/min/g).
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