Key result
Vasopressin infusion during exercise decreases collateral zone blood flow by ~30%, worsening hypoperfusion.
Why the study?
Active constriction of coronary collateral vessels may worsen hypoperfusion of collateral-dependent myocardium during exercise, but this mechanism was not previously tested.
Does vasopressin infusion reduce myocardial blood flow to collateral-dependent myocardium during exercise in a canine model?
Does vasopressin infusion reduce myocardial blood flow to collateral-dependent myocardium during exercise in a canine model?
Effect estimate: 30 +/- 5% decrease
p-value: p=<0.01
Active constriction of collateral and coronary resistance vessels by vasopressin can worsen hypoperfusion of collateral-dependent myocardium during exercise.
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Collateral vasoconstriction may limit flow to dependent myocardium during exercise; leaves open relevance to human coronary disease.
Foreman et al. (1991) studied Collateral-dependent myocardium (n=7). Vasopressin infusion vs. Control conditions (exercise without vasopressin) was evaluated on Blood flow to the collateral zone during exercise (30 +/- 5% decrease, p=<0.01). Infusion of vasopressin during exercise produced a 30% decrease in blood flow to the collateral zone (p<0.01), demonstrating that active constriction of collateral vessels can worsen hypoperfusion.
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