The effect of cardiac hypertrophy on the coronary collateral circulation.
Why the study?
Does left ventricular hypertrophy alter coronary collateral circulation?
Population
9 dogs with renal hypertension and left ventricular hypertrophy and 17 control dogs; 5 patients with aortic…
Comparison
Left ventricular hypertrophy vs Controls without left ventricular hypertrophy
Design
Preclinical
Authors
Discussion
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Member takes
Implication
LVH does not alter collateral resistance in this model; leaves open effects on human ischemia protection.
Structured PICO
Does left ventricular hypertrophy alter coronary collateral circulation?
P
Population
9 dogs with renal hypertension and left ventricular hypertrophy (LVH) and 17 control dogs; 5 patients with aortic valve disease, LVH, and normal coronary arteries, and 6 patients without LVH who had normal left anterior descending coronary arteries.
I
Intervention
Left ventricular hypertrophy (due to renal hypertension in dogs or aortic valve disease in humans)
C
Comparator
Controls without left ventricular hypertrophy
O
Outcome
Coronary collateral resistance (in dogs) and systolic wall thickening during transient coronary occlusion (in humans)surrogate
Left ventricular hypertrophy is not associated with altered coronary collateral resistance or functional evidence of enhanced collateral circulation.
Cite This Study
Harrison et al. (1985) studied this question.