Key result
Intravenous indomethacin caused a 40% decrease in retrograde flow (p<0.01) and a 20% decrease in microvascular collateral flow (p<0.05) in dogs with well-developed coronary collateral vessels.
Why the study?
Does indomethacin reduce blood flow through well-developed coronary collateral vessels in a dog model of coronary occlusion?
Population
8 dogs studied 4-6 months after occlusion of the anterior descending coronary artery to stimulate collateral…
Comparison
Indomethacin 5 mg/kg i.v. vs Baseline measurements before indomethacin…
Design
Preclinical
Follow-up
20 minutes
Authors
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Indomethacin may impair collateral perfusion in canine models; leaves open relevance to human coronary disease.
Does indomethacin reduce blood flow through well-developed coronary collateral vessels in a dog model of coronary occlusion?
p-value: p=<0.01
Cyclooxygenase blockade with indomethacin significantly reduces blood flow through well-developed coronary collateral vessels, indicating they are under tonic influence of vasodilator prostaglandins.
Altman et al. (1992) studied Coronary collateral vessels after coronary artery occlusion (n=8). Indomethacin vs. Baseline (before administration) was evaluated on Retrograde blood flow and microvascular collateral flow (p=<0.01). Intravenous indomethacin caused a 40% decrease in retrograde flow (p<0.01) and a 20% decrease in microvascular collateral flow (p<0.05) in dogs with well-developed coronary collateral vessels.
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