What question did this study set out to answer?

To determine whether well-developed coronary collateral vessels retain endothelial-dependent vasodilator responses after chronic coronary occlusion.

February 1, 1993AJP Heart and Circulatory Physiology

Endothelial function in well-developed canine coronary collateral vessels

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Why the study?

Do endothelial-dependent vasodilators increase coronary collateral blood flow in dogs with well-developed coronary collateral vessels?

Population

13 dogs 4-6 months after embolic occlusion of the left anterior descending coronary artery (LAD)

Comparison

Endothelial-dependent vasodilators introduced… vs Nitroglycerin and basal conditions

Design

Preclinical

Authors

JAJohn D. AltmanGeneral Cardiology DDDaniel DulasUnited Heart and Vascular Clinic TPTodd PavekUniversity of Minnesota

Discussion

Member takes

Implication

Supports intact endothelial-dependent mechanisms in canine coronary collaterals; leaves open translation to human disease.

Key Points

To determine whether well-developed coronary collateral vessels retain endothelial-dependent vasodilator responses after chronic coronary occlusion.
Evaluated 13 dogs 4–6 months after embolic occlusion of the left anterior descending coronary artery (LAD).
Measured collateral flow through LAD retrograde flow collection and radiolabeled microspheres during left main coronary artery agonist infusions.
Assessed the role of vasodilator prostaglandins via cyclooxygenase blockade using intravenous indomethacin (5 mg/kg).
Endothelial-dependent agonists acetylcholine and bradykinin significantly increased collateral blood flow by 21 ± 7% (P < 0.05) and 25 ± 8% (P < 0.05), respectively, matching the 28 ± 8% increase from nitroglycerin.
Indomethacin decreased basal retrograde flow by 30 ± 9% but did not attenuate maximum collateral flow increases evoked by acetylcholine, bradykinin, or nitroglycerin.

Structured PICO

Do endothelial-dependent vasodilators increase coronary collateral blood flow in dogs with well-developed coronary collateral vessels?

Population

13 dogs 4-6 months after embolic occlusion of the left anterior descending coronary artery (LAD)

Intervention

Endothelial-dependent vasodilators (acetylcholine and bradykinin) introduced into the left main coronary artery, with and without cyclooxygenase blockade (indomethacin 5 mg/kg iv)

Comparator

Nitroglycerin (endothelial-independent vasodilator) and basal conditions

Outcome

Responses of coronary collateral blood flow (sum of retrograde flow and continuing tissue flow)surrogate

Intact endothelial-dependent vasodilator mechanisms are present in well-developed coronary collateral circulation in a canine model.

Cite This Study

Altman et al. (1993) studied this question.

synapsesocial.com/papers/6a11fb2607103abb49ad1096 https://doi.org/10.1152/ajpheart.1993.264.2.h567

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Endothelial function in well-developed canine coronary collateral vessels

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Endothelial function in well-developed canine coronary collateral vessels

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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