February 1, 1994AJP Heart and Circulatory Physiology
Regulation of native collateral vessel dilation after coronary occlusion in the dog
Why the study?
What mechanisms mediate the progressive dilation of native coronary collaterals after coronary occlusion in a dog model?
Population
Anesthetized dogs with native collaterals identified between the left anterior descending and left…
Comparison
Left anterior descending coronary occlusion… vs Baseline conditions prior to occlusion
Design
Preclinical
Follow-up
15 minutes
Authors
Discussion
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Member takes
Implication
ATP-sensitive K+ channels mediate collateral dilation after occlusion in dogs; extends mechanistic insights but should not yet inform clinical practice.
Structured PICO
What mechanisms mediate the progressive dilation of native coronary collaterals after coronary occlusion in a dog model?
P
Population
Anesthetized dogs (n=12) with native collaterals identified between the left anterior descending and left circumflex arteries
I
Intervention
Left anterior descending coronary occlusion, with administration of NG-nitro-L-arginine (1 mg/min intracoronary) or glibenclamide (10(-5) M)
C
Comparator
Baseline conditions prior to occlusion
O
Outcome
Change in collateral vessel diameter measured by fluorescence angiography at 1 and 15 minutes post-occlusionsurrogate
Dilation of native coronary collaterals after acute occlusion is mediated by activation of ATP-sensitive K+ channels rather than endothelium-derived relaxing factor.
Cite This Study
Lamping et al. (1994) studied this question.