Key result
Well-developed canine coronary collateral vessels exhibit contractile responses to vasoconstrictors similar to those of native medium-diameter coronary arteries, indicating they possess active vasomotor tone.
This preclinical study demonstrates that well-developed coronary collateral vessels in dogs exhibit contractile behavior similar to native medium-sized coronary arteries when exposed to various vasoactive substances.
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May inform collateral-targeted ischemia models; leaves open human translation of vasomotor responses.
This study examines the responses of coronary collateral vessels to various vasoconstrictors and compares them with responses of 3 different divisions of the native coronary arterial trees in dogs. Only high concentrations of phenylephrine induced contractions in collateral vessels and medium coronary arteries, whereas even a high concentration of this agent did not affect small coronary arteries. Lower concentrations of serotonin or ergonovine elicited contractions in collateral vessels, and medium and large coronary arteries, but even a high concentration of these agents did not affect small coronary arteries. Angiotensin II (10(-7) M) elicited prominent contractions in the following order: small vessels, collateral vessels, medium and large coronary arteries. These results indicate that well-developed collateral vessels behave like native medium diameter coronary artery, and that the tonus of collateral vessels is possibly influenced by various vasoactive substances.
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Akita et al. (1984) studied Coronary collateral vessel reactivity (n=25). Vasoconstrictors (phenylephrine, serotonin, ergonovine, angiotensin II) vs. Native coronary arteries (large, medium, small) was evaluated on Contractile response (isometric force) to vasoconstrictors. Well-developed canine coronary collateral vessels exhibit contractile responses to vasoconstrictors similar to those of native medium-diameter coronary arteries, indicating they possess active vasomotor tone.
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