Population
Canine model of Ameroid occlusion of the left circumflex (LCX) coronary artery
Comparison
In vitro exposure to vasoactive agonists in… vs In vitro exposure to the same agonists in…
Design
Preclinical
Authors
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May heighten ischemic risk in collateral-dependent regions; leaves open relevance to human chronic coronary syndromes.
Collateral-dependent coronary arteries distal to a chronic occlusion exhibit enhanced alpha-adrenergic vasoconstriction and impaired vasorelaxation to adenosine, driven by altered smooth muscle reactivity and decreased endothelial nitric oxide synthesis.
Rapps et al. (1997) studied this question.
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