What does this research mean for the field?

Sensitivity to 5-hydroxytryptamine is greater in proximal coronary arteries, while sensitivity to angiotensin II is greater in distal coronary arteries of dogs and monkeys. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To compare contractile responses of dog and monkey coronary arteries to different vasoconstrictor agents.

May 1, 1984British Journal of PharmacologyOpen Access

Regional differences in the response to vasoconstrictor agents of dog and monkey isolated coronary arteries

Q: What is the clinical evidence from this study?

Population: Isolated coronary arteries. Intervention: Vasoconstrictor agents (KCl, 5-HT, Angiotensin II, PGF2 alpha, c-TXA2) vs. Different sizes of arteries (large, medium, small). Primary outcome: Contractile responses.

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Key result

Sensitivity to 5-hydroxytryptamine was greater in proximal coronary arteries, while sensitivity to angiotensin II was greater in distal coronary arteries of dogs and monkeys.

Population

Helical strips of dog and monkey epicardial coronary arteries of different sizes (large, medium, and small)

Comparison

Exposure to vasoconstrictor agents: KCl… vs Comparison across artery sizes and species

Design

Preclinical

Authors

KMKunihisa MiwaMiwa Internal Medicine Clinic NTNoboru TodaNational Institute of Advanced Industrial Science and Technology

Discussion

Member takes

Implication

Should not change clinical practice; leaves open segmental coronary receptor targeting for future translational studies.

Key Points

To compare contractile responses of dog and monkey coronary arteries to different vasoconstrictor agents.
Isolated helical strips of dog and monkey epicardial coronary arteries were tested.
Vasoconstrictor agents tested include KCl, 5-hydroxytryptamine, angiotensin II, prostaglandin F2 alpha, and carbocyclic thromboxane A2.
Contractions were measured across different artery sizes: large, medium, and small.
Contractions induced by 5-HT were greater in large arteries of dogs but equal in medium and small arteries of monkeys.
Angiotensin II caused greater contractions in small arteries for both species, with significant responses in distal arteries.
Prostaglandin F2 alpha contractions were greater in large and medium arteries of dogs, but not different in monkeys.

Structured PICO

Population

Helical strips of dog and monkey epicardial coronary arteries of different sizes (large, medium, and small)

Intervention

Exposure to vasoconstrictor agents: KCl (30mM), 5-hydroxytryptamine (5-HT) (10(-9) - 2 X 10(-6) M), angiotensin II (AII) (10(-7) M), prostaglandin F2 alpha (PGF2 alpha), and carbocyclic thromboxane A2 (c-TXA2)

Comparator

Comparison across artery sizes (large, medium, small) and species (dog vs. monkey)

Outcome

Contractile responses to vasoconstrictor agentssurrogate

The sensitivity and/or population of 5-HT receptors are greater in proximal coronary arteries, whereas angiotensin II receptors are greater in distal coronary arteries in dogs and monkeys.

Cite This Study

Miwa et al. (1984) studied Isolated coronary arteries. Vasoconstrictor agents (KCl, 5-HT, Angiotensin II, PGF2 alpha, c-TXA2) vs. Different sizes of arteries (large, medium, small) was evaluated on Contractile responses. Sensitivity to 5-hydroxytryptamine was greater in proximal coronary arteries, while sensitivity to angiotensin II was greater in distal coronary arteries of dogs and monkeys.

synapsesocial.com/papers/6a15984a79ff98d0de4edd0f https://doi.org/10.1111/j.1476-5381.1984.tb16471.x

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Regional differences in the response to vasoconstrictor agents of dog and monkey isolated coronary arteries

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Regional differences in the response to vasoconstrictor agents of dog and monkey isolated coronary arteries

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider