What question did this study set out to answer?

To evaluate and compare the contractile and relaxant responses of isolated monkey coronary arteries of varying diameters to catecholamines and transmural electrical stimulation.

December 1, 1981Circulation ResearchOpen Access

Response of isolated monkey coronary arteries to catecholamines and to transmural electrical stimulation.

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Population

Helically cut strips of monkey coronary arteries of different sizes and dog coronary arteries of medium size

Comparison

Exposure to catecholamines and transmural… vs Comparison across different artery sizes and…

Design

Preclinical

Authors

NTNoboru TodaToyama College

Discussion

Member takes

Implication

Species differences in coronary adrenoceptor responses caution against canine model extrapolation; leaves open primate-to-human translation for adrenergic therapies.

Key Points

To evaluate and compare the contractile and relaxant responses of isolated monkey coronary arteries of varying diameters to catecholamines and transmural electrical stimulation.
Helically cut strips of large, medium, and small isolated monkey coronary arteries were precontracted with prostaglandin F2 alpha or potassium ions.
Vascular responses were recorded following exposure to norepinephrine, epinephrine, isoproterenol, and transmural electrical stimulation (2, 5, and 20 Hz), both with and without phentolamine or propranolol.
Parallel responses to catecholamines and transmural stimulation were assessed in medium-sized canine coronary artery strips for comparative analysis.
Norepinephrine induced only contractions in large monkey arteries, concentration-dependent biphasic actions (contraction at low and relaxation at high doses) in medium arteries, and only relaxations in small arteries.
Transmural electrical stimulation produced frequency-dependent contractions in medium monkey arteries that reversed to propranolol-sensitive relaxations after phentolamine treatment.
Medium dog coronary arteries exhibited only relaxations to electrical stimulation and catecholamines, indicating greater alpha-adrenoceptor predominance and contractile consistency in monkey vessels.

Structured PICO

Population

Helically cut strips of monkey coronary arteries of different sizes (large, medium, small) and dog coronary arteries of medium size

Intervention

Exposure to catecholamines (norepinephrine, epinephrine, isoproterenol) and transmural electrical stimulation (2, 5, and 20 Hz)

Comparator

Comparison across different artery sizes (large, medium, small) and between species (monkey vs. dog)

Outcome

Vascular response (contraction or relaxation)surrogate

This preclinical study demonstrates species and vessel-size differences in coronary artery adrenoceptor distribution, with monkey arteries showing more consistent contractile responses to norepinephrine than dog arteries.

Cite This Study

Noboru Toda (1981) studied this question.

synapsesocial.com/papers/6a8aa35120b5dc5751ec6ad0 https://doi.org/10.1161/01.res.49.6.1228

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Implication

Species differences in coronary adrenoceptor responses caution against canine model extrapolation; leaves open primate-to-human translation for adrenergic therapies.

Response of isolated monkey coronary arteries to catecholamines and to transmural electrical stimulation.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Response of isolated monkey coronary arteries to catecholamines and to transmural electrical stimulation.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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