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October 1, 1979Journal of Applied Physiology

Increased lung lymph transport without heart failure after coronary ligation in sheep

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Why the study?

Does coronary artery ligation increase lung lymph transport and vascular permeability in anesthetized sheep?

Population

5 anesthetized sheep

Comparison

Coronary artery ligation vs Pre-ligation baseline and left atrial balloon…

Design

Preclinical

Follow-up

2 hours after occlusion

Authors

JCJ. C. CollinsNorfolk and Norwich University Hospitals NHS Foundation TrustTHThomas R. HarrisUniversity of ManchesterCMCharles R. McKeenVanderbilt University

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Implication

Does not alter post-MI edema management; extends sheep-model evidence on permeability but leaves open human relevance.

Structured PICO

Does coronary artery ligation increase lung lymph transport and vascular permeability in anesthetized sheep?

P
Population
5 anesthetized sheep
I
Intervention
Coronary artery ligation
C
Comparator
Pre-ligation baseline (1 h) and left atrial balloon inflation (in 2 sheep)
O
Outcome
Lung lymph flow (QL), clearance of total serum protein and protein fractions, and hemodynamic pressures (PAP, LAP, AP)surrogate

Coronary ligation in sheep increases lung lymph flow and protein clearance, suggesting increased lung vascular permeability rather than just elevated left atrial pressure as a mechanism for post-MI pulmonary edema.

Cite This Study

Collins et al. (1979) studied this question.

synapsesocial.com/papers/6a7e3c301fdb7ee677c768a2https://doi.org/10.1152/jappl.1979.47.4.792
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pulmonary and coronary endothelial effects of acute myocardial ischemia in dogs1982 · 9 citations
  2. 2Effects of coronary flow reduction on lung vascular tissue transport in sheep1983 · 5 citations
  3. 3Pulmonary edema formation with myocardial infarction and left atrial hypertension: intravascular and extravascular pulmonary fluid volumes.1983 · 21 citations
  4. 4Extravascular water content of heart and lungs after acute myocardial ischemia1978 · 29 citations
  5. 5Non-hydrostatic pulmonary edema after coronary artery ligation in dogs. Protective effect of indomethacin.1982 · 26 citations