Why the study?
Does sustained reduction in coronary flow affect lung vascular tissue transport in sheep?
Population
10 halothane-anesthetized sheep with cannulated lymphatic vessels and a carotid-to-left anterior descending…
Comparison
Sustained reduction in coronary flow to 38% of… vs Control group observed at baseline, for 111 min…
Design
Preclinical
Authors
Loading...
May link coronary ischemia to pulmonary vascular changes in animals; leaves open human translation and clinical relevance.
Does sustained reduction in coronary flow affect lung vascular tissue transport in sheep?
Coronary flow reduction increases lung vascular-tissue transport by decreasing the resistance of the microvascular barrier to protein and fluid movement, with increased pressure secondary to left ventricular dysfunction playing a role.
Harris et al. (1983) studied this question.