Why the study?
Does step-wise reduction in coronary blood flow alter regional and global left ventricular contraction and relaxation in open-chest dogs?
Does step-wise reduction in coronary blood flow alter regional and global left ventricular contraction and relaxation in open-chest dogs?
Progressive regional ischemia induces a compensatory hyperkinesia in normally perfused myocardium, delaying global left ventricular cavity dysfunction until coronary flow is severely reduced.
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Regional compensation may mask early global LV impairment in acute ischemia; leaves open translation to human coronary disease.
Sutton et al. (1982) studied this question.
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