Why the study?
Does isoproterenol or acetylstrophanthidin improve left ventricular function in dogs with subacute myocardial infarction?
Population
Dogs in the subacute phase of myocardial infarction following coronary ligation
Comparison
Isoproterenol infusion and acetylstrophanthidin vs Control dogs (without infarction)
Design
Preclinical
Authors
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Digitalis may raise VT risk without LV benefit in subacute MI models; leaves open inotrope selection by infarct size.
Does isoproterenol or acetylstrophanthidin improve left ventricular function in dogs with subacute myocardial infarction?
In a canine model of subacute myocardial infarction, acetylstrophanthidin failed to improve left ventricular function and increased the risk of ventricular tachycardia, suggesting caution with digitalis use in post-MI heart failure.
Hood et al. (1967) studied this question.
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