July 1, 1988Circulation ResearchOpen Access

Acceleration of the wavefront of myocardial necrosis by chronic hypertension and left ventricular hypertrophy in dogs.

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Why the study?

Does hypertension and left ventricular hypertrophy accelerate myocardial necrosis during acute coronary occlusion, and does nitroprusside reduce infarct size in this model?

Population

59 dogs

Comparison

Circumflex coronary artery occlusion followed by… vs Normal control dogs undergoing the same…

Design

Preclinical

Follow-up

Up to 4 hours of reperfusion

Authors

KDKevin C. DellspergerAugusta University JCJ L ClothierUniversity of Iowa JHJ A HartnettUniversity of Iowa

Discussion

Member takes

Implication

Hypertensive LVH accelerates necrosis and lowers survival in acute occlusion models; leaves open nitroprusside translation to patients.

Structured PICO

Does hypertension and left ventricular hypertrophy accelerate myocardial necrosis during acute coronary occlusion, and does nitroprusside reduce infarct size in this model?

Population

59 dogs (17 adult mongrel controls, 42 with induced systemic hypertension and left ventricular hypertrophy via single-kidney, single-clip model)

Intervention

Circumflex coronary artery occlusion (1 or 3 hours) followed by reperfusion, with or without nitroprusside infusion (to reduce mean arterial pressure to 100 mm Hg beginning 1 hour after occlusion)

Comparator

Normal control dogs undergoing the same occlusion/reperfusion protocol, and HT-LVH dogs without nitroprusside

Outcome

Infarct size (infarct-to-risk ratio assessed by triphenyltetrazolium chloride stain) and mortalitysurrogate

Hypertension and left ventricular hypertrophy accelerate myocardial necrosis and increase mortality during acute coronary occlusion, effects that can be attenuated by afterload reduction with nitroprusside.

Cite This Study

Dellsperger et al. (1988) studied this question.

synapsesocial.com/papers/6a7ea742d14c4cd8047983e4 https://doi.org/10.1161/01.res.63.1.87

Topics

Hypertension management

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Acceleration of the wavefront of myocardial necrosis by chronic hypertension and left ventricular hypertrophy in dogs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Acceleration of the wavefront of myocardial necrosis by chronic hypertension and left ventricular hypertrophy in dogs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider