Why the study?
Does decreasing arterial pressure to normotension reduce infarct size and sudden death in dogs with chronic hypertension and LVH following acute coronary occlusion?
Population
123 conscious dogs with chronic renal hypertension and left ventricular hypertrophy undergoing acute…
Comparison
Decreasing arterial pressure to normotension via… vs Control values
Design
Preclinical
Follow-up
48 hours
Authors
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BP normalization attenuates infarct size and sudden death despite LVH in dogs; hypothesis-generating and should not yet inform human practice.
Does decreasing arterial pressure to normotension reduce infarct size and sudden death in dogs with chronic hypertension and LVH following acute coronary occlusion?
In a canine model, hypertension rather than left ventricular hypertrophy appears to be the critical factor driving increased infarct size and sudden death following acute coronary occlusion.
Inou et al. (1987) studied this question.
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