Key result
Adrenergic neurone blockade largely prevented the decrease in blood flow and the development of infarction following coronary occlusion in dogs, whereas propranolol and atropine had no significant effect.
Why the study?
Does adrenergic neurone blockade prevent decreased blood flow and infarction following coronary occlusion in dogs?
Population
Dogs undergoing ligation of the descending branch of the left coronary artery
Comparison
Adrenergic neurone blockade, propranolol, or… vs Acute ligation without pharmacological…
Design
Preclinical
Authors
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May implicate vasospasm in experimental infarction; leaves open clinical relevance of adrenergic neurone blockade pending human trials.
Does adrenergic neurone blockade prevent decreased blood flow and infarction following coronary occlusion in dogs?
Adrenergic neurone blockade, but not propranolol or atropine, prevents the decrease in blood flow and infarction following acute coronary occlusion in a canine model, suggesting a vasospastic element in myocardial infarction.
Grayson et al. (1968) studied Myocardial infarction. Adrenergic neurone blockade was evaluated on Blood flow and development of infarction. Adrenergic neurone blockade largely prevented the decrease in blood flow and the development of infarction following coronary occlusion in dogs, whereas propranolol and atropine had no significant effect.
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