Key result
Only drugs that increase the transventricular driving pressure gradient, such as oxyfedrine and noradrenaline, increased blood flow through the acutely ischaemic canine myocardium.
Why the study?
How do various drugs affect blood flow and oxygen handling in acutely ischaemic canine myocardium?
Population
Canine model of acute myocardial ischaemia produced by acute ligation of the anterior descending branch of…
Comparison
Various drugs including lidoflazine, oxyfedrine… vs Normal myocardium and comparison between…
Design
Preclinical
Authors
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Transventricular pressure gradient may determine ischaemic flow in canine models; hypothesis-generating and requires human translation studies before any clinical consideration.
How do various drugs affect blood flow and oxygen handling in acutely ischaemic canine myocardium?
In acute myocardial ischaemia, blood flow to the ischaemic region is primarily determined by transventricular driving pressure rather than direct coronary vasodilation.
Marshall et al. (1974) studied Acute myocardial ischaemia (canine model). Various drugs (lidoflazine, oxyfedrine, isoprenaline, glucagon, noradrenaline) was evaluated on Blood flow and oxygen handling in normal and acutely ischaemic regions. Only drugs that increase the transventricular driving pressure gradient, such as oxyfedrine and noradrenaline, increased blood flow through the acutely ischaemic canine myocardium.
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