Key result
An experimental canine model of myocardial infarction enables simultaneous measurement of blood flow and oxygen consumption in normal and ischemic myocardium after acute coronary ligation.
Population
Dog model for experimental myocardial infarction
Comparison
Acute coronary artery ligation vs Normal areas of the myocardium
Design
Preclinical
Follow-up
up to four hours
Authors
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No immediate clinical application; leaves open whether this canine model advances understanding of human post-infarction metabolism.
This study describes a canine model for evaluating regional metabolic and blood flow changes following acute myocardial infarction.
Marshall et al. (1974) studied this question. An experimental canine model of myocardial infarction enables simultaneous measurement of blood flow and oxygen consumption in normal and ischemic myocardium after acute coronary ligation.
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