What is the clinical evidence from this study?

Study design: Other. Population: acute myocardial infarction (n=23). Intervention: 100% oxygen. Primary outcome: changes in the infarction size.

What does this research mean for the field?

Administration of 100% oxygen during acute myocardial infarction increases the infarcted area rather than providing a favorable therapeutic benefit. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1977Cardiovascular Research

Effects of oxygen on acute myocardial infarction: a thermographic study in the dog

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Key result

100% oxygen increases infarct size in dogs with acute MI.

n=23

Why the study?

Does 100% oxygen administration reduce infarction size in a dog model of acute myocardial infarction?

Population

n=23 dogs with experimentally induced acute myocardial infarction

Design

Preclinical

Authors

AMAnnika MalmKarolinska Institutet MAM ArboreliusUppsala University Hospital SBS. BornmyrLund University

Discussion

Member takes

Implication

100% oxygen may enlarge experimental infarcts; leaves open whether it harms or benefits patients with acute MI.

Structured PICO

Does 100% oxygen administration reduce infarction size in a dog model of acute myocardial infarction?

Population

23 dogs with experimentally induced acute myocardial infarction evaluated for changes in infarction size during oxygen administration.

Intervention

100% oxygen administration

Outcome

Changes in infarction size measured by thermographysurrogate

High oxygen supply (100%) does not appear to have a favorable effect on experimentally induced acute myocardial infarction in dogs, and may actually increase infarct size.

Limitations

In 13 animals the cool area was not sufficiently uniform to allow accurate measurement.
In 13 animals the cool area was not sufficiently uniform to allow accurate measurement

Cite This Study

Malm et al. (1977) studied acute myocardial infarction (n=23). 100% oxygen was evaluated on changes in the infarction size. Administration of 100% oxygen to dogs with experimentally induced acute myocardial infarction increased the infarcted area in 20 of 23 animals, suggesting no favorable effect.

synapsesocial.com/papers/6aa7d5dedafa71edbfae5aa3 https://doi.org/10.1093/cvr/11.6.512

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Effects of oxygen on acute myocardial infarction: a thermographic study in the dog

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Effects of oxygen on acute myocardial infarction: a thermographic study in the dog

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider