Why the study?
Does inhalation of oxygen in high concentration alter circulatory and metabolic parameters in patients with acute myocardial infarction?
Does inhalation of oxygen in high concentration alter circulatory and metabolic parameters in patients with acute myocardial infarction?
High-concentration oxygen inhalation in acute myocardial infarction alters hemodynamics, generally decreasing cardiac output while increasing blood pressure and systemic vascular resistance, alongside improving oxygenation and reducing lactate levels.
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High-concentration oxygen was associated with hemodynamic changes in acute MI; leaves open effects on outcomes and should not yet change practice.
The circulatory and metabolic effects of inhalation of oxygen in high concentration were investigated in 50 patients with acute myocardial infarction. The heart rate, arterial blood pressure, cardiac out-put, blood gas tensions, pH, and lactate and pyruvate levels were measured. In general, oxygen inhalation produced a fall in cardiac output and stroke volume and a rise in blood pressure and systemic vascular resistance. In a small number of patients with very low cardiac out-puts there was a rise in output. A substantial rise in arterial oxygen tension was obtained even in patients with low initial values. The raised arterial blood lactate levels which were frequently present were reduced after oxygen. The therapeutic implications of these effects are discussed.
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Kenmure et al. (1968) studied this question.
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