Key result
Oxygen therapy in acute coronary syndrome has conflicting data regarding its efficacy and potential harmful effects, questioning current guidelines and emphasizing the need for large clinical trials.
Why the study?
Does oxygen treatment provide benefit or harm in patients with acute coronary syndrome?
Systematic Review
Does oxygen treatment provide benefit or harm in patients with acute coronary syndrome?
Routine oxygen supplementation in acute coronary syndrome may have potential harmful effects, challenging current guidelines and highlighting the need for large clinical trials.
Questions routine oxygen use in MI due to potential harm; challenges guidelines and calls for definitive RCTs.
Oxygen supplementation is a standard treatment for all patients who present with acute coronary syndrome, regardless of oxygen saturation levels. Most of the data regarding the function of oxygen in myocardial infarction is based on a limited number of basic and clinical studies. We performed a systematic literature review that explores the basic and clinical data on the function of oxygen in ischaemic heart disease and myocardial infarction. This review discusses many aspects of oxygen treatment: (i) basic studies on the effects of oxygen in ischaemia and the potential cardiovascular effects of oxygen metabolites; (ii) clinical trials that have assessed the value of inhaled oxygen, supersaturated oxygen, and intracoronary injection of hyperoxaemic solutions in myocardial infarction; and (iii) the haemodynamic effects of oxygen in various clinical scenarios and its direct effects on the coronary vasculature. Our findings suggest that there are conflicting data on the effects of oxygen treatment. Further, the potential harmful effects of oxygen must be considered, particularly in myocardial infarction. These findings question the current guidelines and recommendations and emphasize the need for large clinical trials.
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Shuvy et al. (2013) conducted a systematic review in Acute coronary syndrome. Oxygen therapy was evaluated. Oxygen therapy in acute coronary syndrome has conflicting data regarding its efficacy and potential harmful effects, questioning current guidelines and emphasizing the need for large clinical trials.
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