What question did this study set out to answer?

To determine the effects of high-concentration oxygen administration on coronary hemodynamics and myocardial oxygen metabolism in individuals with and without coronary artery disease.

April 1, 1972CirculationOpen Access

Coronary Hemodynamics and Myocardial Oxygen Metabolism during Oxygen Breathing in Patients with and without Coronary Artery Disease

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Why the study?

Does high concentration oxygen breathing improve coronary hemodynamics and myocardial oxygen metabolism in patients with and without coronary artery disease?

Population

15 subjects

Comparison

Oxygen in high concentration administered for… vs Baseline (before oxygen breathing)

Design

Other

Follow-up

7-10 minutes

Authors

WGWilliam GanzInterventional / Structural Cardiology RDROBERTO DONOSOCedars-Sinai Medical Center HMHarold S. MarcusCedars-Sinai Medical Center

Discussion

Member takes

Implication

Oxygen may aid myocardial metabolism in CAD; hypothesis-generating and should not yet change practice.

Key Points

To determine the effects of high-concentration oxygen administration on coronary hemodynamics and myocardial oxygen metabolism in individuals with and without coronary artery disease.
Administered high-concentration oxygen (arterial pO2 > 400 mm Hg) for 7–10 minutes to 15 participants (N=6 with normal coronary arteries, N=9 with coronary artery disease).
Evaluated systemic hemodynamics, coronary sinus blood flow, coronary vascular resistance, and coronary arteriovenous oxygen differences.
Calculated left ventricular oxygen consumption and myocardial lactate extraction percentages before and during hyperoxic breathing.
Oxygen administration reduced heart rate and cardiac index across both groups, while coronary sinus blood flow decreased from 158 ± 11 to 131 ± 13 ml/min in controls and from 151 ± 14 to 138 ± 14 ml/min in coronary patients due to increased coronary vascular resistance.
Left ventricular oxygen consumption decreased from 21.5 ± 2.1 to 18.2 ± 2.4 ml/min in normal subjects and from 19.9 ± 2.0 to 16.7 ± 1.7 ml/min in the coronary artery disease group.
Myocardial lactate extraction improved from 40 ± 9% to 60 ± 4% in normal controls and from 4 ± 6% to 28 ± 3% in coronary patients, completely reversing myocardial lactate production to extraction in four patients with severe disease.

Structured PICO

Does high concentration oxygen breathing improve coronary hemodynamics and myocardial oxygen metabolism in patients with and without coronary artery disease?

Population

15 subjects (6 with normal coronary arteries and 9 with coronary artery disease, including 4 with severe coronary artery disease)

Intervention

Oxygen in high concentration (arterial pO2 over 400 mm Hg) administered for 7-10 minutes

Comparator

Baseline (before oxygen breathing)

Outcome

Changes in coronary hemodynamics and myocardial oxygen metabolism (heart rate, cardiac index, mean arterial pressure, coronary sinus blood flow, coronary sinus oxygen tension, coronary arteriovenous oxygen difference, left ventricular oxygen consumption, myocardial lactate extraction)surrogate

High concentration oxygen breathing may be beneficial in myocardial ischemia by increasing coronary arterial oxygen tension, reducing myocardial oxygen consumption, and improving myocardial lactate extraction.

Cite This Study

Ganz et al. (1972) studied this question.

synapsesocial.com/papers/6a1e86fc40bc8a3dd769052b https://doi.org/10.1161/01.cir.45.4.763

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Coronary Hemodynamics and Myocardial Oxygen Metabolism during Oxygen Breathing in Patients with and without Coronary Artery Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Coronary Hemodynamics and Myocardial Oxygen Metabolism during Oxygen Breathing in Patients with and without Coronary Artery Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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