Key result
Oxygen breathing increased the pacing rate required to induce angina compared to air breathing (137 vs 129 beats/min; P<0.005), permitting the heart to do more work before coronary insufficiency.
Why the study?
Does oxygen breathing improve the angina threshold in patients with coronary artery disease?
Population
11 patients with arteriographically confirmed coronary artery disease and normal arterial oxygen saturation
Comparison
Oxygen breathing via a close-fitting mask vs Breathing air via a close-fitting mask
Design
Case_series, Single-blind
Follow-up
Acute (during pacing procedure)
Authors
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May increase angina threshold during pacing in CAD; hypothesis-generating and should not change practice.
Does oxygen breathing improve the angina threshold in patients with coronary artery disease?
Absolute Event Rate: 137% vs 129%
p-value: p=<0.005
Oxygen administration acutely improves myocardial metabolism and increases the ischemic threshold in patients with coronary artery disease undergoing atrial pacing.
Horvat et al. (1972) studied Coronary artery disease (n=11). Oxygen breathing vs. Air breathing was evaluated on Pacing rate at which angina developed (beats/min) (p=<0.005). Oxygen breathing increased the pacing rate required to induce angina compared to air breathing (137 vs 129 beats/min; P<0.005), permitting the heart to do more work before coronary insufficiency.
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