Why the study?
Does angina pectoris produced by atrial pacing alter hemoglobin affinity for oxygen in patients with angina?
Population
6 patients with angina pectoris
Comparison
Angina pectoris produced by atrial pacing vs Baseline (rest) before angina
Design
Case_series
Follow-up
Acute (during and after pacing)
Authors
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Should not change angina management from one case; leaves open compensatory role of rapid P50 shift in ischemia.
Does angina pectoris produced by atrial pacing alter hemoglobin affinity for oxygen in patients with angina?
Angina pectoris induces a rapid decrease in hemoglobin affinity for oxygen, which may serve as a compensatory mechanism to enhance myocardial oxygen delivery.
Shappell et al. (1970) studied this question.
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