What is the clinical evidence from this study?

Study design: Other. Population: temporary ischaemic myocardium (n=30). Intervention: Hyperbaric oxygen vs. Controls. Primary outcome: Macroscopic extent of ischaemic area.

What does this research mean for the field?

Hyperbaric oxygen administration immediately following reperfusion of temporary coronary occlusion markedly reduces myocardial ischaemic area and suppresses serious arrhythmias. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1976Cardiovascular Research

Protective effect of hyperbaric oxygen for the temporary ischaemic myocardium. Macroscopic and histological data

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Key result

Hyperbaric oxygen after coronary reperfusion markedly reduces ischaemic area and suppresses serious arrhythmias.

n=30

Why the study?

Does hyperbaric oxygen reduce the ischaemic area in a canine model of temporary coronary artery occlusion?

Population

30 dogs with temporary occlusion of coronary artery (from 30 min to 2 h) produced by ligation

Comparison

Hyperbaric oxygen vs Control group

Design

Preclinical

Follow-up

4 hours (n=20) and 5 days (n=10)

Authors

MKMasaki KawamuraShinshu University KSKeisuke SakakibaraUniversity of Electro-Communications BSBunsaku SakakibaraKobe Gakuin University

Discussion

Member takes

Implication

Does not support clinical use; leaves open translation from this canine reperfusion model.

Structured PICO

Does hyperbaric oxygen reduce the ischaemic area in a canine model of temporary coronary artery occlusion?

Population

30 dogs subjected to temporary coronary artery occlusion (30 min to 2 h) followed by reperfusion, evaluated at 4 hours or 5 days.

Intervention

Hyperbaric oxygen (breathing 100% oxygen at an absolute pressure of 2 atmospheres before and after release of coronary ligation)

Comparator

Control group

Outcome

Macroscopic extent of ischaemic area evaluated using nitroblue tetrazoliumsurrogate

Hyperbaric oxygen therapy immediately after coronary reperfusion reduces myocardial ischaemic injury and suppresses arrhythmias in a canine model.

Cite This Study

Kawamura et al. (1976) studied temporary ischaemic myocardium (n=30). Hyperbaric oxygen vs. Controls was evaluated on Macroscopic extent of ischaemic area. Hyperbaric oxygen at 2 atmospheres immediately after reopening of occluded coronary blood flow markedly reduced the ischaemic area and suppressed serious arrhythmias.

synapsesocial.com/papers/6aa7d5dedafa71edbfae5aa4 https://doi.org/10.1093/cvr/10.5.599

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Protective effect of hyperbaric oxygen for the temporary ischaemic myocardium. Macroscopic and histological data

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Protective effect of hyperbaric oxygen for the temporary ischaemic myocardium. Macroscopic and histological data

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider