Why the study?
Does early hyperbaric oxygenation reduce myocardial necrosis and acute mortality in rats after coronary occlusion?
Population
217 male Wistar rats subjected to coronary occlusion
Comparison
Hyperbaric oxygenation for 1 h in a hyperbaric… vs Ambient O2
Design
Preclinical, randomly assigned
Follow-up
24 h
Authors
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Hypothesis-generating for HBO post-MI; does not support clinical use and requires human trials.
Does early hyperbaric oxygenation reduce myocardial necrosis and acute mortality in rats after coronary occlusion?
Early hyperbaric oxygenation reduces myocardial infarct size and acute mortality in a rat model of coronary occlusion.
Santos et al. (2009) studied this question.
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