What does this research mean for the field?

Hyperbaric oxygen significantly reduces myocardial infarct size in reperfused myocardium when initiated during ischemia or at the onset of reperfusion. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1993CirculationOpen Access

Hyperbaric oxygen limits infarct size in ischemic rabbit myocardium in vivo.

Q: What are the key findings of this study?

Hyperbaric oxygen during ischemia and reperfusion significantly reduced infarct size compared to 1.0-atm control (9.8% vs 41.5%; P<=0.01).

Q: What is the clinical evidence from this study?

Study design: Other. Population: Myocardial ischemia and reperfusion. Intervention: Hyperbaric oxygen vs. 100% oxygen at 1.0 atm absolute. Primary outcome: Infarction expressed as a percentage of the ischemic zone (p=<=0.01).

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Key result

Hyperbaric oxygen during ischemia and reperfusion cuts infarct size by ~76% versus control.

P<=0.01

Why the study?

Does hyperbaric oxygen reduce infarct size in a rabbit model of myocardial ischemia and reperfusion?

Population

Open-chest rabbit model of myocardial ischemia and reperfusion.

Comparison

Hyperbaric oxygen at 2.5 atm absolute. vs Ventilation with 100% oxygen at 1 atm absolute.

Design

Preclinical

Follow-up

3 hours of reperfusion

Authors

DSD L SterlingUniversity of South Alabama JTJ D ThorntonUniversity of South Alabama ASAlbert N. SwaffordFranciscan Missionaries of Our Lady University

Discussion

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Implication

Hypothesis-generating in rabbit ischemia-reperfusion; leaves open any clinical role pending human trials.

Structured PICO

Does hyperbaric oxygen reduce infarct size in a rabbit model of myocardial ischemia and reperfusion?

Population

Open-chest rabbit model of myocardial ischemia (30 minutes) and reperfusion (3 hours).

Intervention

Hyperbaric oxygen at 2.5 atm absolute (administered during ischemia only, reperfusion only, ischemia and reperfusion, or begun 30 minutes after onset of reperfusion).

Comparator

Ventilation with 100% oxygen at 1 atm absolute.

Outcome

Infarct size measured by triphenyl tetrazolium staining and expressed as a percentage of the ischemic zone.surrogate

Main Result

Absolute Event Rate: 9.8% vs 41.5%

p-value: p=<=0.01

Hyperbaric oxygen limits infarct size in a reperfused rabbit heart model, provided it is initiated no later than the onset of reperfusion.

Cite This Study

Sterling et al. (1993) studied Myocardial ischemia and reperfusion. Hyperbaric oxygen vs. 100% oxygen at 1.0 atm absolute was evaluated on Infarction expressed as a percentage of the ischemic zone (p=<=0.01). Hyperbaric oxygen during ischemia and reperfusion significantly reduced infarct size compared to 1.0-atm control (9.8% vs 41.5%; P<=0.01).

synapsesocial.com/papers/6aa6cb9a014c9b816df4fe31 https://doi.org/10.1161/01.cir.88.4.1931

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Hyperbaric oxygen limits infarct size in ischemic rabbit myocardium in vivo.

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Hyperbaric oxygen limits infarct size in ischemic rabbit myocardium in vivo.

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

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Also Consider