Key result
In the collateral flow-deficient rabbit heart, the percentage of ischemic myocardium infarcted correlated significantly with the duration of ischemia, with 50% of ischemic myocytes necrotizing after 34 minutes of coronary occlusion.
Why the study?
Does the duration of ischemia determine the size and progression of myocardial infarction in a collateral flow deficient species?
Does the duration of ischemia determine the size and progression of myocardial infarction in a collateral flow deficient species?
Effect estimate: r=0.83
p-value: p=<0.01
In a collateral flow deficient model, 50% of ischemic myocardium necrotizes after just 34 minutes of occlusion, with infarction progressing bidirectionally from the midmyocardium.
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Offers rabbit model of rapid midmyocardial necrosis; leaves open human translation and reperfusion timing.
Miura et al. (1989) studied Myocardial Infarction (n=53). Coronary artery occlusion vs. Varying durations of ischemia was evaluated on Percentage of the ischemic zone infarcted (% infarction) (r=0.83, p=<0.01). In the collateral flow-deficient rabbit heart, the percentage of ischemic myocardium infarcted correlated significantly with the duration of ischemia, with 50% of ischemic myocytes necrotizing after 34 minutes of coronary occlusion.
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