What is the clinical evidence from this study?

Study design: Other. Population: Experimental acute coronary artery occlusion (n=23). Intervention: 100% oxygen inhalation vs. Room air. Primary outcome: Regional myocardial blood flow in ischaemic sites (cm3 . min-1 . 100g-1) (p=<0.05).

What does this research mean for the field?

Ventilation with 100% oxygen increases collateral blood flow to ischaemic myocardium while reducing flow to nonischaemic regions following acute coronary artery occlusion. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 1979Cardiovascular Research

Augmentation of collateral blood flow to the ischaemic myocardium by oxygen inhalation following experimental coronary artery occlusion

Q: What are the key findings of this study?

In dogs with acute coronary occlusion, ventilation with 100% oxygen increased regional myocardial blood flow in ischaemic sites from 28 to 32 cm3/min/100g (P<0.05).

Q: What does this research mean for the field?

Ventilation with 100% oxygen increases collateral blood flow to ischaemic myocardium while reducing flow to nonischaemic regions following acute coronary artery occlusion. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

100% oxygen increases ischemic myocardial blood flow ~14% in dogs with acute coronary occlusion.

P<0.05
n=23

Why the study?

The mechanism by which oxygen reduces infarct size was not completely understood.

Does ventilation with 100% oxygen improve regional myocardial blood flow in an experimental dog model of acute coronary artery occlusion?

Population

23 anaesthetised open-chest dogs with acute LAD or apical branch occlusion

Comparison

Ventilation with 100% oxygen vs continuous room air

Design

Controlled animal experimental study

Follow-up

30 min following coronary artery occlusion

Authors

LRL. G. T. RIBEIROBrigham and Women's Hospital ELE. LouieThe Wistar Institute MDMichael A. DavisSouthwest Research Institute

Discussion

Member takes

Implication

Does not support hyperoxia in acute coronary syndromes; leaves open translation of perfusion gains to human infarct reduction.

Structured PICO

Does ventilation with 100% oxygen improve regional myocardial blood flow in an experimental dog model of acute coronary artery occlusion?

Population

23 anaesthetised open-chest dogs with experimental acute occlusions of the left anterior descending coronary artery or its apical branch.

Intervention

Ventilation with 100% oxygen beginning 17 min after occlusion and continuing until the end of the experiment

Comparator

Continuous ventilation with room air

Outcome

Regional myocardial blood flow determined by the microsphere technique at 15 and 30 min following coronary artery occlusionsurrogate

Main Result

Absolute Event Rate: 32% vs 25%

p-value: p=<0.05

Ventilation with 100% oxygen augments perfusion of the ischaemic myocardium in an experimental dog model of acute coronary occlusion, suggesting a mechanism for infarct size reduction.

Cite This Study

RIBEIRO et al. (1979) studied Experimental acute coronary artery occlusion (n=23). 100% oxygen inhalation vs. Room air was evaluated on Regional myocardial blood flow in ischaemic sites (cm3 . min-1 . 100g-1) (p=<0.05). In dogs with acute coronary occlusion, ventilation with 100% oxygen increased regional myocardial blood flow in ischaemic sites from 28 to 32 cm3/min/100g (P<0.05).

synapsesocial.com/papers/6aa7d5dedafa71edbfae5aa2 https://doi.org/10.1093/cvr/13.3.160

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Augmentation of collateral blood flow to the ischaemic myocardium by oxygen inhalation following experimental coronary artery occlusion

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Augmentation of collateral blood flow to the ischaemic myocardium by oxygen inhalation following experimental coronary artery occlusion

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

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