Why the study?
Does a solution of dihydroxyacetone, phosphate, and pyruvate reduce myocardial necrosis in dogs with acute coronary occlusion?
Population
Awake, previously instrumented dogs with acute occlusion of either the left anterior descending or…
Comparison
20 ml/kg infusion of a solution of… vs 20 ml/kg of phosphate and pyruvate solution or…
Design
Preclinical
Follow-up
7-9 days
Authors
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Reduces necrosis in severe canine ischemia; hypothesis-generating for metabolic modulation in human acute coronary syndromes.
Does a solution of dihydroxyacetone, phosphate, and pyruvate reduce myocardial necrosis in dogs with acute coronary occlusion?
Reducing blood oxygen affinity with glycolytic intermediates decreases the extent of myocardial necrosis for the same degree of ischemia in a canine model of acute coronary occlusion.
Pantely et al. (1981) studied this question.
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