Reduction of infarct size by oxygen inhalation following acute coronary occlusion.
Why the study?
Does oxygen inhalation reduce myocardial ischemic injury and infarct size in a dog model of acute coronary occlusion?
Population
39 anesthetized dogs undergoing experimental left anterior descending coronary artery occlusion.
Comparison
Inspiration of O2-enriched air vs Inspiration of room air (FIO2 0.20)
Design
Preclinical
Follow-up
24 hours
Authors
Discussion
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Implication
Hypothesis-generating for supplemental oxygen in acute coronary occlusion; human trials needed before clinical consideration.
Structured PICO
Does oxygen inhalation reduce myocardial ischemic injury and infarct size in a dog model of acute coronary occlusion?
P
Population
39 anesthetized dogs (15 for acute occlusion, 24 for 24-hour occlusion) undergoing experimental left anterior descending coronary artery occlusion.
I
Intervention
Inspiration of O2-enriched air (fraction of inspired oxygen [FIO2] 0.40 or 1.0)
C
Comparator
Inspiration of room air (FIO2 0.20)
O
Outcome
Myocardial ischemic injury (measured by epicardial ST-segment elevation) and infarct size (measured by myocardial creatine phosphokinase activity and histological necrosis)surrogate
In an experimental dog model, oxygen inhalation (FIO2 0.40) following acute coronary occlusion significantly decreased acute ischemic injury and reduced the development of myocardial necrosis.
Cite This Study
Maroko et al. (1975) studied this question.