Key result
In dogs with acute alloxan-induced pulmonary edema, lung fluids contained high protein concentrations (alveolar fluid 5.2 g/100 ml), indicating a freely permeable alveolar epithelial membrane.
Population
11 anesthetized dogs with acute alloxan-induced pulmonary edema
Design
Preclinical
Authors
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Characterizes permeability edema in canine model; leaves open clinical translation to human ARDS.
In alloxan-induced pulmonary edema, lung fluids contain high concentrations of protein, indicating the alveolar epithelial membrane becomes freely permeable to protein molecules.
Vreim et al. (1976) studied Acute alloxan-induced pulmonary edema (n=11). Alloxan was evaluated on Protein composition of lung fluids. In dogs with acute alloxan-induced pulmonary edema, lung fluids contained high protein concentrations (alveolar fluid 5.2 g/100 ml), indicating a freely permeable alveolar epithelial membrane.
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