Analysis of airway fluid protein concentration in neurogenic pulmonary edema

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Population

alpha-chloralose-anesthetized dogs

Comparison

Intracisternal administration of veratrine vs Alloxan or combined left atrial pressure and…

Design

Preclinical

Authors

Discussion

Demonstrates mixed mechanisms in canine neurogenic edema; leaves open relevance to human pathophysiology.

Population

alpha-chloralose-anesthetized dogs

Intervention

Intracisternal administration of veratrine (40 micrograms/kg)

Comparator

Alloxan (permeability edema model) or combined left atrial pressure and volume overload (hemodynamic edema model)

Outcome

Airway fluid-to-plasma protein (A/P) concentration ratios for total proteins and endogenous protein fractionssurrogate

Veratrine-induced neurogenic pulmonary edema in dogs is driven by a combination of hemodynamic and increased permeability mechanisms.

M. B. Maron (1987) studied this question.

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