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May 1, 1981Journal of neurosurgery

Experimental neurogenic pulmonary edema

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Population

Normal cats

Design

Preclinical

Follow-up

30 minutes

Authors

JHJulian T. HoffTotal (France)MNMerry NishimuraSan Francisco General HospitalJGJose Garcia-Uria

Discussion

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Implication

Challenges hypertension requirement in neurogenic pulmonary edema models; leaves open direct sympathetic lung effects pending clinical studies.

Structured PICO

P
Population
Normal cats
I
Intervention
Increasing intracranial pressure with an intraventricular infusion of mock cerebrospinal fluid, with systemic arterial pressure controlled by blood withdrawal to maintain constant cerebral perfusion pressure (CPP) at 50, 20, and 0 mm Hg for 30 minutes
O
Outcome
Development of neurogenic pulmonary edema (NPE)

Systemic arterial hypertension is not an essential stimulus for the development of neurogenic pulmonary edema, suggesting direct lung effects from intense sympathetic discharge.

Cite This Study

Hoff et al. (1981) studied this question.

synapsesocial.com/papers/6a93f0ba40c15fb141fc1168https://doi.org/10.3171/jns.1981.54.5.0627

Topics

Hypertension management
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Sympathetic Nerve Stimulation on Pulmonary Vascular Resistance in the Dog1973 · 77 citations
  2. 2Neural Structures Involved in the Genesis of ‘Preoptic Pulmonary Edema,’ Gastric Erosions and Behavior Changes1956 · 106 citations
  3. 3Experimental Pulmonary Edema. IV. Pulmonary Edema Accompanying Trauma to the Brain.1950 · 62 citations