Neurogenic pulmonary edema is an underdiagnosed clinical syndrome characterized by acute pulmonary edema following a significant central nervous system insult, likely driven by a catecholamine surge.
This review outlines the pathophysiologic mechanisms of neurogenic pulmonary edema and proposes diagnostic criteria to identify patients who may benefit from sympathetic interference such as alpha-adrenergic blockade.
Neurogenic pulmonary edema (NPE) is a clinical syndrome characterized by the acute onset of pulmonary edema following a significant central nervous system (CNS) insult. The etiology is thought to be a surge of catecholamines that results in cardiopulmonary dysfunction. A myriad of CNS events, including spinal cord injury, subarachnoid hemorrhage (SAH), traumatic brain injury (TBI), intracranial hemorrhage, status epilepticus, meningitis, and subdural hemorrhage, have been associated with this syndrome 1 – 5 . Although NPE was identified over 100 years ago, it is still underappreciated in the clinical arena. Its sporadic and relatively unpredictable nature and a lack of etiologic-specific diagnostic markers and treatment modalities may in part be responsible for its poor recognition at the bedside. In this manuscript, we will review the anatomical origin of NPE, outline the various possible pathophysiologic mechanisms responsible for its development, and propose a clinical framework for the classification of NPE.
Davison et al. (Sun,) conducted a review in Neurogenic pulmonary edema. Neurogenic pulmonary edema is an underdiagnosed clinical syndrome characterized by acute pulmonary edema following a significant central nervous system insult, likely driven by a catecholamine surge.