Key result
Spinal cord compression induced neurogenic pulmonary edema in both normotensive and hypertensive rats, demonstrating that hypertension-associated impairment of baroreflex sensitivity does not prevent NPE.
Why the study?
Does hypertension-associated impairment of baroreflex sensitivity prevent neurogenic pulmonary edema induced by spinal cord compression in rats?
Does hypertension-associated impairment of baroreflex sensitivity prevent neurogenic pulmonary edema induced by spinal cord compression in rats?
Moderate impairment of baroreflex sensitivity in hypertensive rats does not exert sufficient protective effects against neurogenic pulmonary edema development following acute spinal cord compression.
Answers are grounded in this paper and cite their sources.
Hypertension-related baroreflex impairment does not prevent NPE after spinal compression in rats; leaves open relevance to human spinal cord injury.
Neurogenic pulmonary edema (NPE), which is induced by acute spinal cord compression (SCC) under the mild (1.5 %) isoflurane anesthesia, is highly dependent on baroreflex-mediated bradycardia because a deeper (3 %) isoflurane anesthesia or atropine pretreatment completely abolished bradycardia occurrence and NPE development in rats subjected to SCC. The aim of the present study was to evaluate whether hypertension-associated impairment of baroreflex sensitivity might exert some protection against NPE development in hypertensive animals. We therefore studied SCC-induced NPE development in two forms of experimental hypertension - spontaneously hypertensive rats (SHR) and salt hypertensive Dahl rats, which were reported to have reduced baroreflex sensitivity. SCC elicited NPE in both hypertensive models irrespective of their baroreflex sensitivity. It is evident that a moderate impairment of baroreflex sensitivity, which was demonstrated in salt hypertensive Dahl rats, does not exert sufficient protective effects against NPE development.
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Šedý et al. (2011) studied Neurogenic pulmonary edema (n=38). Spinal cord compression vs. Intact controls (no spinal cord injury) was evaluated on Pulmonary index (lung weight/body weight x 100) (p=<0.05). Spinal cord compression induced neurogenic pulmonary edema in both normotensive and hypertensive rats, demonstrating that hypertension-associated impairment of baroreflex sensitivity does not prevent NPE.
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