Key result
In dogs, reducing plasma protein concentrations to 47% of control lowered the critical left atrial pressure required for fluid transudation into the lungs from 24 mm Hg to 11 mm Hg.
Authors
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Critical LA pressure threshold for edema identified; leaves open human validation and oncotic modulation.
Absolute Event Rate: 11% vs 24%
Guyton et al. (1959) studied Pulmonary edema (n=97). Elevated left atrial pressure and decreased plasma protein concentration vs. Normal plasma protein concentrations was evaluated on Critical left atrial pressure for fluid transudation into the lungs. In dogs, reducing plasma protein concentrations to 47% of control lowered the critical left atrial pressure required for fluid transudation into the lungs from 24 mm Hg to 11 mm Hg.
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