Key result
Intracisternal administration of veratrine in dogs induced massive alveolar edema in 11 of 17 animals, accompanied by severe systemic and pulmonary hypertension.
Population
17 alpha-chloralose-anesthetized dogs
Design
Preclinical
Follow-up
1 h
Authors
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Provides a canine model for neurogenic pulmonary edema; extends mechanistic research but leaves clinical translation open.
Intracisternal veratrine administration in dogs provides a useful model of neurogenic pulmonary edema, driven by both hemodynamic and permeability mechanisms.
M. B. Maron (1985) studied Neurogenic pulmonary edema (n=17). Intracisternal administration of veratrine was evaluated on Development of alveolar edema and hemodynamic changes. Intracisternal administration of veratrine in dogs induced massive alveolar edema in 11 of 17 animals, accompanied by severe systemic and pulmonary hypertension.
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