Experimental Pulmonary Embolism
Population
Normal mongrel dogs
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Embolism type modulates PGE1 effects in canines; leaves open whether macro- versus microembolism requires distinct vasodilator strategies in patients.
Structured PICO
P
Population
Normal mongrel dogs
I
Intervention
Induction of pulmonary macroembolism (autologous blood clot) or microembolism (lycopodium spores), followed by Prostaglandin E1 infusion
O
Outcome
Pulmonary hemodynamics (pulmonary artery pressure, total pulmonary resistance, pulmonary blood volume, pulmonary vascular compliance) and systemic arterial pressuresurrogate
In a canine model, macro- and microembolism produce different effects on pulmonary blood volume and vascular compliance, and respond differently to Prostaglandin E1 infusion.
Cite This Study
Alpert et al. (1974) studied this question.