Why the study?
Does acute experimental recurrent pulmonary microembolization alter ventricular function and coronary blood flow in anesthetized adult mongrel dogs?
Population
33 anesthetized (pentobarbital soda 30 mg/kg) adult mongrel dogs, weighing 12 to 28 kilograms
Comparison
Acute experimental recurrent pulmonary… vs Baseline (normal state before loading)
Design
Preclinical
Authors
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Enables mechanistic investigation of pulmonary embolism-induced cardiac failure in dogs; leaves open clinical translation.
Does acute experimental recurrent pulmonary microembolization alter ventricular function and coronary blood flow in anesthetized adult mongrel dogs?
This preclinical study describes a canine model to investigate the mechanisms of irreversible cardiac failure and coronary blood flow changes during acute pulmonary embolization.
Kazuo Tomita (1976) studied this question.
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