Why the study?
Do interventions like descending aorta ligation, norepinephrine, or isoproterenol improve hemodynamics and biventricular geometry in a canine model of acute right ventricular pressure overload?
Population
Canine model of acute right ventricular pressure overload induced by lycopodium pulmonary embolization
Design
Preclinical
Authors
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Hypothesis-generating for systemic pressure support in acute RV overload models; should not change clinical practice without human trials.
Do interventions like descending aorta ligation, norepinephrine, or isoproterenol improve hemodynamics and biventricular geometry in a canine model of acute right ventricular pressure overload?
In acute right ventricular pressure overload, maintaining systemic pressure with norepinephrine or aortic ligation restores biventricular geometry and RV function, whereas isoproterenol is ineffective.
Yamashita et al. (1989) studied this question.
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