Key result
Acute pulmonary embolization during critical right coronary artery stenosis in dogs caused a 60% decline in coronary blood flow and severe myocardial dysfunction, which reversed upon release of the constriction.
Why the study?
Does acute pulmonary embolization affect right ventricular performance and coronary hemodynamics in a canine model with right coronary artery stenosis?
Population
8 open-chest dogs with underlying critical stenosis of the right coronary artery (RCA)
Comparison
Acute pulmonary embolization vs Baseline state prior to embolization and state…
Design
Preclinical
Authors
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RV dysfunction during acute PE with critical RCA stenosis may reflect lost coronary reserve; hypothesis-generating in this model and leaves open human relevance.
Does acute pulmonary embolization affect right ventricular performance and coronary hemodynamics in a canine model with right coronary artery stenosis?
p-value: p=<0.05
Right ventricular function deteriorates in response to increased afterload when coronary vascular reserve is absent and aortic pressure decreases.
Hans‐Joachim Priebe (1990) studied Pulmonary hypertension and right coronary artery stenosis (canine model) (n=8). Acute pulmonary embolization during critical right coronary artery stenosis vs. Baseline / Release of RCA constriction was evaluated on Right ventricular performance, coronary hemodynamics, and gas exchange (p=<0.05). Acute pulmonary embolization during critical right coronary artery stenosis in dogs caused a 60% decline in coronary blood flow and severe myocardial dysfunction, which reversed upon release of the constriction.
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