Key result
In a canine model of acute pulmonary hypertension, hydralazine improved RV performance and gas exchange, whereas nitroglycerin and prostaglandin E1 exerted no beneficial cardiopulmonary effects.
Why the study?
Do vasodilators (nitroglycerin, prostaglandin E1, hydralazine) improve RV function and gas exchange in a canine model of acute pulmonary hypertension?
Population
8 open-chest dogs with acute pulmonary embolization causing acute pulmonary hypertension
Comparison
Nitroglycerin, prostaglandin E1, and hydralazine vs Baseline state
Design
Preclinical
Authors
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May inform vasodilator selection in experimental acute PH; leaves open human translation and optimal RV support.
Do vasodilators (nitroglycerin, prostaglandin E1, hydralazine) improve RV function and gas exchange in a canine model of acute pulmonary hypertension?
In a canine model of acute pulmonary hypertension, hydralazine improved cardiopulmonary hemodynamics and gas exchange, whereas nitroglycerin and prostaglandin E1 were detrimental.
Hans‐Joachim Priebe (1988) studied Acute pulmonary hypertension and respiratory insufficiency (n=8). Nitroglycerin, prostaglandin E1, and hydralazine was evaluated on Right ventricular function and gas exchange. In a canine model of acute pulmonary hypertension, hydralazine improved RV performance and gas exchange, whereas nitroglycerin and prostaglandin E1 exerted no beneficial cardiopulmonary effects.
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