June 1, 1969Circulation ResearchOpen Access

Inadequacy of Perivascular Edema Hypothesis to Account for Distribution of Pulmonary Blood Flow in Lung Edema

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Population

24 isolated, perfused dog lungs

Comparison

Induction of pulmonary edema vs Different pressure-flow conditions

Design

Preclinical

Authors

BRBlair RitchieQueen's University GSGERTRAUD SCHAUBERGERUniversity of California San Francisco Medical Center NSNorman C. StaubTulane University

Discussion

Member takes

Implication

Challenges edema-based explanations for flow inversion; leaves open zone-specific mechanisms in edematous lungs.

Structured PICO

Population

24 isolated, perfused dog lungs (6 with spontaneous edema in zone II, 6 with alloxan-induced edema in zone II, 6 with high venous pressure in zone III, and 6 rapidly frozen lungs)

Intervention

Induction of pulmonary edema (spontaneous, alloxan-induced, or high venous pressure)

Comparator

Different pressure-flow conditions (Zone II vs Zone III)

Outcome

Pulmonary blood flow per unit lung volume (Q/V) and flow inversionsurrogate

The accumulation of interstitial perivascular edema does not adequately explain the inversion of pulmonary blood flow distribution in lung edema.

Cite This Study

Ritchie et al. (1969) studied this question.

synapsesocial.com/papers/6a82b30e23a6926b671e1391 https://doi.org/10.1161/01.res.24.6.807

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Inadequacy of Perivascular Edema Hypothesis to Account for Distribution of Pulmonary Blood Flow in Lung Edema

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inadequacy of Perivascular Edema Hypothesis to Account for Distribution of Pulmonary Blood Flow in Lung Edema

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider