Why the study?
How does pulmonary gas exchange change during the induction of acute pulmonary edema in anesthetized dogs?
How does pulmonary gas exchange change during the induction of acute pulmonary edema in anesthetized dogs?
In a canine model of acute pulmonary edema, hypoxemia is primarily caused by increased venous admixture due to alveolar closure, which can be reversed by forcible lung inflation.
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PaO2 monitoring may miss early edema in models; leaves open whether shunt reversal by inflation applies clinically.
Said et al. (1964) studied this question.
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