Acid-base status affects gas exchange in canine oleic acid pulmonary edema

32 pentobarbital sodium-anesthetized intact dogs with oleic acid (0.06 ml/kg) induced pulmonary edema

Induction of metabolic acidosis (pH 7.20 with HCl), metabolic alkalosis (pH 7.60 with Carbicarb), respiratory acidosis (hypercapnia, pH 7.20), or isolated hypercapnia

Baseline state before induction of acid-base changes

Pulmonary gas exchange (intrapulmonary shunt) and pulmonary hemodynamics (pulmonary arterial minus wedge pressure difference)surrogate